Publications and Key Points TARE
| Publication | Keypoints |
|---|---|
| 1. BIERMAN, H R et al. “Studies on the blood supply of tumors in man. III. Vascular patterns of the liver by hepatic arteriography in vivo.” Journal of the National Cancer Institute vol. 12,1 (1951): 107-31. 2. BREEDIS, C, and G YOUNG. “The blood supply of neoplasms in the liver.” The American journal of pathology vol. 30,5 (1954): 969-77. 3. Blanchard RJ, Lafave jw, kim ys, frye cs, ritchie wp, perry jf. treatment of patients with advanced cancer utilizing Y90 microspheres. Cancer. 1965;18:375–380. | 1. Liver tumor receive blood supply from hepatic artery and not the portal vein. 2. More than 80% blood supply is from hepatic artery supply |
| Grady E.D., Sale W., Nicolson W.P., Jr., Rollins L.C. Intra-arterial radioisotopes to treat cancer. Am Surg. 1960;26:678–684. | Animal model - Feasibility of treating tumor with Y90 |
| Simon N., Warner R.R., Baron M.G., Rudavsky A.Z. Intra-arterial irradiation of carcinoid tumors of the liver. AJR Am J Roentgenol. 1968;102:552–561. | Role of intraarterial irradiation in Hepatic NET and carcinoid syndrome |
| Ackerman, N B et al. “The blood supply of experimental liver metastases. I. The distribution of hepatic artery and portal vein blood to "small" and "large" tumors.” Surgery vol. 66,6 (1969): 1067-72. | Arterial supply to HCC is developed after reaching a size of 3 mm |
| Taylor, I., R. Bennett, and S. Sherriff. "The blood supply of colorectal liver metastases." British journal of cancer 38.6 (1978): 749-756. | 1. mCRC blood supply is from hepatic artery. 2. When hepatic artery is ligated portal supply is significantly increased. |
| 1. Meade V.M., Burton M.A., Gray B.N., Self G.W. Distribution of different sized microspheres in experimental hepatic tumours. Eur J Cancer Clin Oncol. 1987;23:37–41. 2. Anderson J.H., Angerson W.J., Willmott N., Kerr D.J., McArdle C.S., Cooke T.G. Regional delivery of microspheres to liver metastases: The effects of particle size and concentration on intrahepatic distribution. Br J Cancer. 1991;64:1031–1034. | 1. Number of particle per unit mass also effects the homogeneity of distribution (minimum of 4000 beads/gram of liver) 2. Distribution in terminal arterial circulation without penetration into venous circulation (15um) (terminal arterioles with diameter less than 50 um) 3. 12.5, 25, 40 um = T/N 0.5, 1.4, 1.8 (Anderson) |
| Burton, M A et al. “Selective internal radiation therapy: distribution of radiation in the liver.” European journal of cancer & clinical oncology vol. 25,10 (1989): 1487-91. doi:10.1016/0277-5379(89)90109-0 | 1. Intra arterial injection of angiotensin II (Bolus dose of 50ug pulsed into Main hepatic artery -wait for 30 sec - then SIR sphere injection) resulted in T/N ratio 6:1 to 10:1, Otherwise 2:1 to 3:1 in group not injected with angiotensin II 2. CEA levels at 3 months - decreased by 70% |
| Gray B, Van Hazel G, Hope M, Burton M, Moroz P, Anderson J, Gebski V. Randomised trial of SIR-Spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Ann Oncol. 2001;12:1711–1720 | mCRC (70 patients) single Y90 hepatic arterial infusion plus monthly infusion of floxuridine vs floxuridine alone (Objective response = 50% vs 24%, p = 0.03) |