Cancer of the Liver Italian Program (CLIP) Score

The Cancer of the Liver Italian Program (CLIP) score is a prognostic tool used to assess the severity and prognosis of liver cancer. It is commonly used in clinical practice to help guide treatment decisions. The CLIP score takes into account several factors including the size and number of tumors, the presence of vascular invasion, and the level of alpha-fetoprotein (AFP) in the blood. By assigning points based on these factors, the CLIP score provides a numerical value that correlates with the likelihood of survival and helps physicians determine the most appropriate treatment approach for each individual patient. The higher the CLIP score, the higher the risk of poor outcomes and the more aggressive the treatment options maybe considered.¹

The CLIP score helps in stratifying patients into different prognostic groups, which in turn guides treatment decisions. It provides valuable information to physicians about the patient’s overall liver function, tumor burden, and vascular invasion, which are important factors in determining the appropriate treatment strategy. ¹

ParametersPoints
Child-Pugh Score
A
B
C

0 Point
1 Point
2 Points
Tumor morphology
uninodular and extension ≤ 50%
multinodular and extension ≤ 50%
massive or extension > 50%

0 Point
1 Point
2 Points
AFP at baseline
< 400 ng/ml
≥ 400 ng/mL

0 Point
1 Point
Portal vein thrombosis
No
Yes

0 Point
1 Point
Total
CLIP score ranges from 0-6, with median survival by CLIP score as follows:
0 = 42.5 months
1 = 32.0 months
2 = 16.5 months
3 = 4.5 months
4 = 2.5 months
5-6 = 1 month
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