ABCR Score in Hepatocellular Carcinoma
The ABCR (standing for alphafetoprotein, BCLC, Child-Pugh status and Response) score incorporates four parameters that are associated with patient outcomes and treatment-related factors. Two of these parameters are observed at baseline and are typically linked with overall survival (OS): the BCLC (Barcelona Clinic Liver Cancer) stage and the alpha-fetoprotein (AFP) level.
The other two parameters in the ABCR score are treatment-related. One parameter is associated with treatment efficacy, specifically the tumor response to therapy. The second treatment-related parameter is associated with treatment toxicity, specifically an increase of more than one point in the Child-Pugh score, which measures liver function.
| Parameters | Points |
|---|---|
| Radiological response Present Absent | - 3 Point 0 point |
| AFP at baseline < 200 ng/ml ≥ 200 ng/mL | 0 Point 1 Point |
| BCLC stage at baseline A B C | 0 Point 2 Point 3 Points |
| Child-Pugh Score increase by ≥ 2 Points | 2 Points |
| Total | -3 to 3 = Low risk after Re TACE ≥ 4 = Dismal Prognosis after Re TACE |
- Adhoute X, Penaranda G, Naude S, Raoul JL, Perrier H, Bayle O, Monnet O, Beaurain P, Bazin C, Pol B, Le Folgoc G. Retreatment with TACE: the ABCR SCORE, an aid to the decision-making process. Journal of hepatology. 2015 Apr 1;62(4):855-62.
- Karademir S. Staging of hepatocellular carcinoma. Hepatoma Res. 2018;4:58.
- Kinoshita, Akiyoshi et al. “Staging systems for hepatocellular carcinoma: Current status and future perspectives.” World journal of hepatology vol. 7,3 (2015): 406-24. doi:10.4254/wjh.v7.i3.406